Guadalupe County Vacations & Trips from $563
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Your Guadalupe County Vacation
Our Guadalupe County vacation packages provide an easy, affordable and immersive way to enjoy all that this unique destination has to offer. If it's nature and culture you're looking for, this is the place to be. Be sure to include Santa Rosa and Vaughn on your list of cities to explore when planning your trip to Guadalupe County. Expedia has flights, hotels and everything else you need to help you organize your own customized Guadalupe County vacation today.
Top destinations in Guadalupe County
Santa Rosa
Vaughn
The Latest Guadalupe County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express & Suites Los Alamos Entrada Park by IHG
$710
per person
Nov 23 - Nov 27
found 9 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Santa Fe (SAF)
8.8/10 Excellent! (807 reviews)
It was good, other than the water being turned off at 4pm for 10 hours during a soccer tournament. But that was probably beyond the hotels control.
Reviewed on Sep 8, 2026
Hampton Inn & Suites Los Alamos White Rock
$703
per person
Nov 23 - Nov 27
found 9 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Santa Fe (SAF)
9/10 Wonderful! (734 reviews)
Nice property for a quick stay. We had a large room with a living room and kitchen. The kitchen table was obviously in the wrong location when we came into the room. Oddly, whole place services were laid out for 4 people. We asked for wine glasses because the only glasses in the room held about 20 oz. But there were no wine glasses or juice glasses to be found. Nonetheless, a nice property if you are in the area.
Reviewed on Sep 12, 2026
Find the Best Guadalupe County Vacation Packages
Guadalupe County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Albuquerque Intl. Sunport Airport (ABQ) |
Top Sights | Blue Hole, Santa Rosa Lake State Park and Blue Hole |
Guadalupe County Hotel Deals
La Quinta Inn & Suites by Wyndham Santa Rosa
2277 Historic Route 66 Santa Rosa NM
Fully refundableReserve now, pay when you stay
$136 nightly
$154 total
Sep 15 - Sep 16
Total with taxes and fees
9.2/10 Wonderful! (1,551 reviews)
"The hotel was good. The staff was friendly and provided information about activities nearby. Breakfast and parking were provided. We enjoyed our stay."
Reviewed on Sep 12, 2026
Comfort Inn Santa Rosa on Route 66
2524 Historic Route 66 Santa Rosa NM
Fully refundable
$95 nightly
$108 total
Oct 1 - Oct 2
Total with taxes and fees
8.4/10 Very Good! (1,004 reviews)
"We stopped off over night while traveling just to sleep eat breakfast and take off again. Breakfast was good and facility was clean."
Reviewed on Sep 12, 2026
Hotel Blue 66, BW Signature Collection
2533 Historic Route 66 Santa Rosa NM
Fully refundableReserve now, pay when you stay
$93 nightly
$106 total
Sep 20 - Sep 21
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Guadalupe County attractions
Photo by Peter Allman
Route 66 Auto Museum
7.8/10 (100 reviews)
You can study the exhibits at Route 66 Auto Museum, a museum with a story of its own, during your trip to Santa Rosa. While in this quaint area, you can savor the top-notch restaurants.
St. Rose of Lima Catholic Church
7.8/10 (48 reviews)
After visiting St. Rose of Lima Catholic Church, make a plan to see the other sights and activities in Santa Rosa. While in this quaint area, you can savor the top-notch restaurants.
Blue Hole
8.2/10 (187 reviews)
You can take time to visit Blue Hole during your travels to Santa Rosa. While in this quaint area, you can savor the top-notch restaurants.
Santa Rosa Lake State Park
7.8/10 (51 reviews)
You can take time to visit Santa Rosa Lake State Park during your travels to Santa Rosa. While you're here, you can savor the top-notch restaurants.
Bass Lake
Commune with nature and explore the great outdoors at Bass Lake during your travels in Santa Rosa. While you're here, you can savor the top-notch restaurants.
Santa Rosa Golf Course
Enjoy a round of golf in Santa Rosa at Santa Rosa Golf Course. While you're here, you can savor the top-notch restaurants.
Post Lake
Commune with nature and explore the great outdoors at Post Lake during your travels in Santa Rosa. While you're here, you can savor the top-notch restaurants.
Moise Memorial Library
After visiting Moise Memorial Library, make a plan to see the other sights and activities in Santa Rosa. While you're here, you can savor the top-notch restaurants.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
